7FTL
Crystal Structure of human cyclic GMP-AMP synthase in complex with 8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid
Summary for 7FTL
Entry DOI | 10.2210/pdb7ftl/pdb |
Group deposition | To be published (G_1002263) |
Descriptor | Cyclic GMP-AMP synthase, ZINC ION, (2P)-8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | nucleotidyltransferase, cyclic gmp-amp synthase, cgas, dna-binding, activator dna, pattern recognition receptor, innate immune response, viral dna recognition, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42770.02 |
Authors | Leibrock, L.,Benz, J.,Groebke-Zbinden, K.,Brunner, M.,Rudolph, M.G. (deposition date: 2023-02-08, release date: 2024-02-21) |
Primary citation | Groebke-Zbinden, K.,Vandemeulebroucke, A.,Hilbert, M.,Rudolph, M.G. Crystal Structure of a human cyclic GMP-AMP synthase complex To be published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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