7FRS
PanDDA analysis group deposition of ground-state model of PTP1B
Summary for 7FRS
Entry DOI | 10.2210/pdb7frs/pdb |
Group deposition | PanDDA analysis group deposition of ground-state model (G_1002256) |
Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL (3 entities in total) |
Functional Keywords | pandda, diamond i24 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 37467.70 |
Authors | Mehlman, T.,Biel, J.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.E.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. (deposition date: 2022-10-26, release date: 2022-11-23, Last modification date: 2024-05-22) |
Primary citation | Skaist Mehlman, T.,Biel, J.T.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. Elife, 12:-, 2023 Cited by PubMed: 36881464DOI: 10.7554/eLife.84632 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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