7FRP
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with XST00000245b
7FRP の概要
エントリーDOI | 10.2210/pdb7frp/pdb |
Group deposition | PanDDA analysis group deposition (G_1002255) |
分子名称 | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-(2-methyl-1,3-thiazol-4-yl)thiophene-2-carboxylic acid, ... (4 entities in total) |
機能のキーワード | pandda, diamond i24 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37692.99 |
構造登録者 | Mehlman, T.,Biel, J.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.E.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. (登録日: 2022-10-24, 公開日: 2022-11-23, 最終更新日: 2024-05-22) |
主引用文献 | Skaist Mehlman, T.,Biel, J.T.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. Elife, 12:-, 2023 Cited by PubMed: 36881464DOI: 10.7554/eLife.84632 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.77 Å) |
構造検証レポート
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