7FRL

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with Z2856434917

7FRL の概要

• エントリーDOI: 10.2210/pdb7frl/pdb
• Group deposition: PanDDA analysis group deposition (G_1002255)
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1-(3,4-dimethoxyphenyl)methanamine, ... (4 entities in total)
• 機能のキーワード: pandda, diamond i24 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37634.91

構造登録者

Mehlman, T.,Biel, J.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.E.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A. (登録日: 2022-10-24, 公開日: 2022-11-23, 最終更新日: 2023-03-29)

• 主引用文献: Skaist Mehlman, T.,Biel, J.T.,Azeem, S.M.,Nelson, E.R.,Hossain, S.,Dunnett, L.,Paterson, N.G.,Douangamath, A.,Talon, R.,Axford, D.,Orins, H.,von Delft, F.,Keedy, D.A.; Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B.; Elife, 12:-, 2023; PubMed: 36881464; DOI: 10.7554/eLife.84632

実験手法

X-RAY DIFFRACTION (1.79 Å)