7FQI

Crystal Structure of human Legumain in complex with (2S)-N-[(1S)-3-amino-1-cyano-3-oxopropyl]-1-[1-[4-[(2,4-difluorophenyl)methoxy]phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

Summary for 7FQI

• Entry DOI: 10.2210/pdb7fqi/pdb
• Group deposition: To be published (G_1002245)
• Descriptor: Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(2R)-4-amino-1-imino-4-oxobutan-2-yl]-1-(1-{4-[(2,4-difluorophenyl)methoxy]phenyl}cyclopropane-1-carbonyl)-L-prolinamide, ... (5 entities in total)
• Functional Keywords: cysteine protease, allosteric inhibitor, asparaginyl endopeptidase, alzheimer's disease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 155712.13

Authors

Ehler, A.,Benz, J.,Bartels, B.,Rudolph, M.G. (deposition date: 2022-10-05, release date: 2023-10-11, Last modification date: 2023-11-15)

• Primary citation: Bartels, B.,Kuhn, B.,Benz, J.,Rudolph, M.G.; Crystal Structure of a human Legumain complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)