7FKY

PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment P04G05 from the F2X-Universal Library

7FKY の概要

• エントリーDOI: 10.2210/pdb7fky/pdb
• Group deposition: PanDDA analysis group deposition (G_1002241)
• 分子名称: Pre-mRNA-splicing factor 8, A1 cistron-splicing factor AAR2, 1-{[(2-methylphenyl)methyl]carbamoyl}cyclopropane-1-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: fragmax, fragmaxapp, fragment screening, rnaseh like domain, u5 snrnp assembly, splicing
• 由来する生物種: Saccharomyces cerevisiae S288C; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66177.48

構造登録者

Barthel, T.,Wollenhaupt, J.,Lima, G.M.A.,Wahl, M.C.,Weiss, M.S. (登録日: 2022-08-26, 公開日: 2022-11-02, 最終更新日: 2022-11-30)

• 主引用文献: Barthel, T.,Wollenhaupt, J.,Lima, G.M.A.,Wahl, M.C.,Weiss, M.S.; Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites.; J.Med.Chem., 65:14630-14641, 2022; PubMed: 36260741; DOI: 10.1021/acs.jmedchem.2c01165

実験手法

X-RAY DIFFRACTION (1.59 Å)