7FCZ

Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor

7FCZ の概要

• エントリーDOI: 10.2210/pdb7fcz/pdb
• 分子名称: Receptor-interacting serine/threonine-protein kinase 1, N-[(3S)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide (3 entities in total)
• 機能のキーワード: immune system-inhibitor complex, immune system/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68250.82

構造登録者

Su, H.X.,Xie, H.,Nie, T.Q.,Li, M.J.,Xu, Y.C. (登録日: 2021-07-15, 公開日: 2022-01-19, 最終更新日: 2023-11-29)

• 主引用文献: Yang, X.,Lu, H.,Xie, H.,Zhang, B.,Nie, T.,Fan, C.,Yang, T.,Xu, Y.,Su, H.,Tang, W.,Zhou, B.; Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis.; Angew.Chem.Int.Ed.Engl., 61:e202114922-e202114922, 2022; PubMed: 34851543; DOI: 10.1002/anie.202114922

実験手法

X-RAY DIFFRACTION (2.21 Å)