7FBK

Crystal structure of SARS-CoV-2 receptor binding domain N501Y mutant in complex with neutralizing nanobody 20G6

7FBK の概要

• エントリーDOI: 10.2210/pdb7fbk/pdb
• 分子名称: Spike protein S1, New antigen receptor variable domain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, spike glycoprotein, rbd, vnar, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 81267.94

構造登録者

Zhu, J.,Xu, T.,Feng, B.,Liu, J. (登録日: 2021-07-11, 公開日: 2022-07-13, 最終更新日: 2023-11-29)

• 主引用文献: Feng, B.,Chen, Z.,Sun, J.,Xu, T.,Wang, Q.,Yi, H.,Niu, X.,Zhu, J.,Fan, M.,Hou, R.,Shao, Y.,Huang, S.,Li, C.,Hu, P.,Zheng, P.,He, P.,Luo, J.,Yan, Q.,Xiong, X.,Liu, J.,Zhao, J.,Chen, L.; A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape.; Small Methods, 6:e2200387-e2200387, 2022; PubMed: 35583124; DOI: 10.1002/smtd.202200387

実験手法

X-RAY DIFFRACTION (1.9 Å)