7F9S

Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Febrifugine (FF)

Summary for 7F9S

• Entry DOI: 10.2210/pdb7f9s/pdb
• Descriptor: Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (8 entities in total)
• Functional Keywords: protein translation, inhibitor, prs, atp pocket, double drug, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 1
• Total formula weight: 59196.61

Authors

Manickam, Y.,Malhotra, N.,Sharma, A. (deposition date: 2021-07-04, release date: 2022-10-05, Last modification date: 2023-11-29)

• Primary citation: Malhotra, N.,Manickam, Y.,Sharma, A.; TgPRS with double inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.861 Å)