7F9Q

Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and Febrifugine

7F9Q の概要

• エントリーDOI: 10.2210/pdb7f9q/pdb
• 分子名称: Prolyl-tRNA synthetase (ProRS), 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, 3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ... (5 entities in total)
• 機能のキーワード: protein translation, inhibitor, prs, atp pocket, double drug, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Toxoplasma gondii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117472.34

構造登録者

Manickam, Y.,Malhotra, N.,Sharma, A. (登録日: 2021-07-04, 公開日: 2022-10-05, 最終更新日: 2023-11-29)

• 主引用文献: Malhotra, N.,Manickam, Y.,Sharma, A.; TgPRS with double inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (2.796 Å)