7EVZ

Cryo-EM structure of cenerimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein

7EVZ の概要

• エントリーDOI: 10.2210/pdb7evz/pdb
• EMDBエントリー: 31342
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: homo sapiens, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 177807.74

構造登録者

Yuan, Y.,Jia, G.W.,Shao, Z.H.,Su, Z.M. (登録日: 2021-05-24, 公開日: 2021-09-29, 最終更新日: 2022-02-16)

• 主引用文献: Yuan, Y.,Jia, G.,Wu, C.,Wang, W.,Cheng, L.,Li, Q.,Li, Z.,Luo, K.,Yang, S.,Yan, W.,Su, Z.,Shao, Z.; Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.; Cell Res., 31:1263-1274, 2021; PubMed: 34526663; DOI: 10.1038/s41422-021-00566-x

実験手法

ELECTRON MICROSCOPY (3.07 Å)