7ERH

Crystal structure of WT-TTR in complex with bithionol

Summary for 7ERH

• Entry DOI: 10.2210/pdb7erh/pdb
• Descriptor: Transthyretin, 2,2'-sulfanediylbis(4,6-dichlorophenol), CALCIUM ION, ... (4 entities in total)
• Functional Keywords: amyloidosis, inhibitor, complex, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 35057.24

Authors

Yokoyama, T.,Kashihara, M.,Mizuguchi, M. (deposition date: 2021-05-06, release date: 2021-11-24, Last modification date: 2023-11-29)

• Primary citation: Yokoyama, T.,Kashihara, M.,Mizuguchi, M.; Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.; J.Med.Chem., 64:14344-14357, 2021; PubMed: 34547896; DOI: 10.1021/acs.jmedchem.1c00823

Experimental method

X-RAY DIFFRACTION (1.55 Å)