7ER7

Crystal structure of hyman Biliverdin IX-beta reductase B with Tamibarotene (A80)

7ER7 の概要

• エントリーDOI: 10.2210/pdb7er7/pdb
• 分子名称: Flavin reductase (NADPH), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid, ... (5 entities in total)
• 機能のキーワード: platelets, biliverdin reductase b, blvrb, inhibitors, nadp, thrombovytopenia, tamibarotene, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46987.61

構造登録者

Griesinger, C.,Lee, D.,Ryu, K.S.,Kim, M.,Ha, J.H. (登録日: 2021-05-06, 公開日: 2022-01-19, 最終更新日: 2023-11-29)

• 主引用文献: Kim, M.,Ha, J.H.,Choi, J.,Kim, B.R.,Gapsys, V.,Lee, K.O.,Jee, J.G.,Chakrabarti, K.S.,de Groot, B.L.,Griesinger, C.,Ryu, K.S.,Lee, D.; Repositioning Food and Drug Administration-Approved Drugs for Inhibiting Biliverdin IX beta Reductase B as a Novel Thrombocytopenia Therapeutic Target.; J.Med.Chem., 65:2548-2557, 2022; PubMed: 34957824; DOI: 10.1021/acs.jmedchem.1c01664

実験手法

X-RAY DIFFRACTION (1.7 Å)