7ENG

Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30 (local refinement of the RBD and Fab30)

7ENG の概要

• エントリーDOI: 10.2210/pdb7eng/pdb
• EMDBエントリー: 31210
• 分子名称: Light chain of Fab30, Heavy chain of Fab30, Spike glycoprotein, ... (4 entities in total)
• 機能のキーワード: immune system, viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 191739.22

構造登録者

Wang, X.F.,Zhu, Y.Q. (登録日: 2021-04-16, 公開日: 2022-04-06, 最終更新日: 2022-09-21)

• 主引用文献: Wang, X.,Hu, A.,Chen, X.,Zhang, Y.,Yu, F.,Yue, S.,Li, A.,Zhang, J.,Pan, Z.,Yang, Y.,Lin, Y.,Gao, L.,Zhou, J.,Zhao, J.,Li, F.,Shi, Y.,Huang, F.,Yang, X.,Peng, Y.,Tu, L.,Zhang, H.,Zheng, H.,He, J.,Zhang, H.,Xu, L.,Huang, Q.,Zhu, Y.,Deng, K.,Ye, L.; A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD; Signal Transduct Target Ther, 7:114-, 2022; DOI: 10.1038/s41392-022-00954-8

実験手法

ELECTRON MICROSCOPY (3.59 Å)