7EMJ
Crystal structure of T2R-TTL-Barbigerone complex
Summary for 7EMJ
Entry DOI | 10.2210/pdb7emj/pdb |
Descriptor | Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | tubulin, cancer, cell cycle-inhibitor complex, cell cycle/inhibitor |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 270197.82 |
Authors | Yang, J.H.,Yan, W. (deposition date: 2021-04-14, release date: 2022-04-20, Last modification date: 2024-07-10) |
Primary citation | Yan, W.,Li, Y.,Liu, Y.,Wen, Y.,Pei, H.,Yang, J.,Chen, L. Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton. Phytomedicine, 109:154550-154550, 2023 Cited by PubMed: 36610121DOI: 10.1016/j.phymed.2022.154550 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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