7ELV

Structure of legume lectin domain from Methanocaldococcus jannaschii in apo form

7ELV の概要

• エントリーDOI: 10.2210/pdb7elv/pdb
• 分子名称: legume lectin, (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: lectin, sugar binding protein
• 由来する生物種: Methanocaldococcus jannaschii DSM 2661 (Methanococcus jannaschii)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23295.47

構造登録者

Suguna, K.,Khan, F. (登録日: 2021-04-12, 公開日: 2022-04-20, 最終更新日: 2023-11-29)

主引用文献

Khan, F.,Kaza, S.
Crystal structure of an L-type lectin domain from archaea.
Proteins, 91:456-465, 2023

PubMed Abstract: The crystal structures of an L-type lectin domain from Methanocaldococcus jannaschii in apo and mannose-bound forms have been determined. A thorough investigation of L-type lectin domains from several organisms provides insight into the differences in these domains from different kingdoms of life. While the overall fold of the L-type lectin domain is conserved, differences in the lengths of the carbohydrate-binding loops and significant variations in the Mn -binding site compared to the Ca -binding site are observed. Furthermore, the sequence and phylogenetic analyses suggest that the archaeal L-type lectin domain is evolutionarily closer to the plant legume lectins than to its bacterial or animal counterparts. This is the first report of the biochemical, structural, sequence, and phylogenetic analyses of an L-type lectin domain from archaea and serves to enhance our understanding of the species-specific differences and evolution of L-type lectin domains.

PubMed: 36301308
DOI: 10.1002/prot.26440

実験手法

X-RAY DIFFRACTION (1.5 Å)