7EKB

Crystal structure of 4E10 modified with pyrene acetamide

7EKB の概要

• エントリーDOI: 10.2210/pdb7ekb/pdb
• 分子名称: Fab region of the heavy chain of broadly neutralizing antibody anti-HIV-1 4E10, Fab region of the light chain of the broadly neutralizing anti-HIV-1 antibody 4E10, MPER region of the HIV-1 envelope glycoprotein protein gp41, ... (6 entities in total)
• 機能のキーワード: igg, fab, chemical modification, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49998.86

構造登録者

Caaveiro, J.M.M.,Rujas, E.,Nieva, J.L. (登録日: 2021-04-05, 公開日: 2021-08-11, 最終更新日: 2023-11-29)

• 主引用文献: Rujas, E.,Leaman, D.P.,Insausti, S.,Carravilla, P.,Garcia-Porras, M.,Largo, E.,Morillo, I.,Sanchez-Eugenia, R.,Zhang, L.,Cui, H.,Iloro, I.,Elortza, F.,Julien, J.P.,Eggeling, C.,Zwick, M.B.,Caaveiro, J.M.M.,Nieva, J.L.; Focal accumulation of aromaticity at the CDRH3 loop mitigates 4E10 polyreactivity without altering its HIV neutralization profile.; Iscience, 24:102987-102987, 2021; PubMed: 34505005; DOI: 10.1016/j.isci.2021.102987

実験手法

X-RAY DIFFRACTION (1.45 Å)