7EIL
BRD4-BD1 in complex with LT-909-110
7EIL の概要
エントリーDOI | 10.2210/pdb7eil/pdb |
分子名称 | Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide (3 entities in total) |
機能のキーワード | inhibitor, brd4, bd1, gene regulation |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 15353.75 |
構造登録者 | |
主引用文献 | Kong, B.,Zhu, Z.,Li, H.,Hong, Q.,Wang, C.,Ma, Y.,Zheng, W.,Jiang, F.,Zhang, Z.,Ran, T.,Bian, Y.,Yang, N.,Lu, T.,Zhu, J.,Tang, W.,Chen, Y. Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy Eur.J.Med.Chem., 227:113953-, 2022 Cited by DOI: 10.1016/j.ejmech.2021.113953主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.7 Å) |
構造検証レポート
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