7EI4

Crystal structure of MasL in complex with a novel covalent inhibitor, collimonin C

7EI4 の概要

• エントリーDOI: 10.2210/pdb7ei4/pdb
• 分子名称: Acetyl-CoA C-acyltransferase, (6S,7R,9E)-6,7-bis(oxidanyl)hexadeca-9,15-dien-11,13-diynoic acid (3 entities in total)
• 機能のキーワード: acetyl-coa acetyltransferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: [Empedobacter] haloabium
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 171534.64

構造登録者

Lin, C.C.,Huang, K.F.,Yang, Y.L. (登録日: 2021-03-30, 公開日: 2022-04-06, 最終更新日: 2023-11-29)

• 主引用文献: Lin, C.C.,Hoo, S.Y.,Ma, L.T.,Lin, C.,Huang, K.F.,Ho, Y.N.,Sun, C.H.,Lee, H.J.,Chen, P.Y.,Shu, L.J.,Wang, B.W.,Hsu, W.C.,Ko, T.P.,Yang, Y.L.; Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors.; Commun Biol, 5:454-454, 2022; PubMed: 35551233; DOI: 10.1038/s42003-022-03409-6

実験手法

X-RAY DIFFRACTION (1.66 Å)