7EG1

Cryo-EM structure of DNMDP-induced PDE3A-SLFN12 complex

Summary for 7EG1

• Entry DOI: 10.2210/pdb7eg1/pdb
• EMDB information: 31104
• Descriptor: cGMP-inhibited 3',5'-cyclic phosphodiesterase A, Schlafen family member 12, (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one, ... (5 entities in total)
• Functional Keywords: pde3a, slfn12, dnmdp, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 231275.11

Authors

Liu, N.,Chen, J.,Wang, X.D.,Wang, H.W. (deposition date: 2021-03-23, release date: 2021-11-03, Last modification date: 2022-05-25)

• Primary citation: Chen, J.,Liu, N.,Huang, Y.,Wang, Y.,Sun, Y.,Wu, Q.,Li, D.,Gao, S.,Wang, H.W.,Huang, N.,Qi, X.,Wang, X.; Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells.; Nat Commun, 12:6204-6204, 2021; PubMed: 34707099; DOI: 10.1038/s41467-021-26546-8

Experimental method

ELECTRON MICROSCOPY (3.2 Å)