7EEK

Structure of Human serum albumin-Au compound complex

7EEK の概要

• エントリーDOI: 10.2210/pdb7eek/pdb
• 分子名称: Serum albumin, PALMITOLEIC ACID, 11-methyl-2-oxa-4-thia-6,7-diaza-3$l^{3}-auratricyclo[7.4.0.0^{3,7}]trideca-1(13),5,9,11-tetraen-5-amine (3 entities in total)
• 機能のキーワード: delivery, complex, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 136549.30

構造登録者

Yang, F.,Zhang, J.Z. (登録日: 2021-03-18, 公開日: 2022-03-23, 最終更新日: 2025-08-20)

主引用文献

Zhang, J.,Jiang, M.,Li, S.,Zhang, Z.,Sun, H.,Yang, F.,Liang, H.
Developing a Novel Anticancer Gold(III) Agent to Integrate Chemotherapy and Immunotherapy.
J.Med.Chem., 64:6777-6791, 2021

PubMed Abstract: To effectively treat gastric cancer, we innovatively attempted to develop a metal agent to integrate immunotherapy and chemotherapy by dual targeting the cellular components in the tumor microenvironment (TME) based on the specific residue of human serum albumin (HSA) nanoparticles (NPs). We synthesized a series of Au(III) α-N-heterocyclic thiosemicarbazone compounds and obtained a Au agent () with remarkable cytotoxicity to gastric cancer cells; moreover, we successfully constructed a novel complex NP delivery system. Importantly, the results showed that / NPs effectively inhibited gastric tumor growth and NPs enhanced the therapeutic efficiency, bioavailability, and targeting ability compared with those of alone. Furthermore, the / results revealed that / NPs could integrate chemotherapy and immunotherapy by synergistically attacking two different cellular components in TME at the same time, namely, polarizing the tumor-associated macrophages and inducing apoptosis of gastric cancer cells.

PubMed: 34000198
DOI: 10.1021/acs.jmedchem.1c00050

実験手法

X-RAY DIFFRACTION (2.5 Å)