7EBV

Crystal structure of Aedes aegypti Noppera-bo, glutathione S-transferase epsilon 8, in luteolin- and glutathione-bound form

7EBV の概要

• エントリーDOI: 10.2210/pdb7ebv/pdb
• 分子名称: Glutathione transferase, GLUTATHIONE, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, ... (5 entities in total)
• 機能のキーワード: glutathione, glutathione s-transferase, gst, transferase
• 由来する生物種: Aedes aegypti (Yellowfever mosquito, Culex aegypti)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106973.00

構造登録者

Inaba, K.,Koiwai, K.,Senda, M.,Senda, T.,Niwa, R. (登録日: 2021-03-11, 公開日: 2022-01-26, 最終更新日: 2023-11-29)

主引用文献

Inaba, K.,Ebihara, K.,Senda, M.,Yoshino, R.,Sakuma, C.,Koiwai, K.,Takaya, D.,Watanabe, C.,Watanabe, A.,Kawashima, Y.,Fukuzawa, K.,Imamura, R.,Kojima, H.,Okabe, T.,Uemura, N.,Kasai, S.,Kanuka, H.,Nishimura, T.,Watanabe, K.,Inoue, H.,Fujikawa, Y.,Honma, T.,Hirokawa, T.,Senda, T.,Niwa, R.
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti.
Bmc Biol., 20:43-43, 2022

PubMed Abstract: Mosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There is an urgent need for the development of selective and safe reagents for mosquito control. Flavonoids, a group of chemical substances with variable phenolic structures, such as daidzein, have been suggested as potential mosquito larvicides with less risk to the environment. However, the mode of mosquito larvicidal action of flavonoids has not been elucidated.

PubMed: 35172816
DOI: 10.1186/s12915-022-01233-2

実験手法

X-RAY DIFFRACTION (1.5 Å)