7EBD

Bacterial STING in complex with c-di-GMP

Summary for 7EBD

• Entry DOI: 10.2210/pdb7ebd/pdb
• Descriptor: TIR-like domain-containing protein, ACETATE ION, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ... (4 entities in total)
• Functional Keywords: second messenger, complex, cyclic dinucleotide, antiviral pathway, signaling protein
• Biological source: Prevotella corporis
• Total number of polymer chains: 2
• Total formula weight: 38070.75

Authors

Ko, T.-P.,Wang, Y.-C.,Yang, C.-S.,Hou, M.-H.,Chen, Y. (deposition date: 2021-03-09, release date: 2021-09-15, Last modification date: 2022-01-19)

• Primary citation: Ko, T.-P.,Wang, Y.-C.,Yang, C.-S.,Hou, M.-H.,Chen, C.-J.,Chiu, Y.-F.,Chen, Y.; Crystal structure and functional implication of bacterial STING.; Nat Commun, 13:26-26, 2022; PubMed: 35013136; DOI: 10.1038/s41467-021-26583-3

Experimental method

X-RAY DIFFRACTION (2.25 Å)