7EAZ

Cryo-EM structure of SARS-CoV-2 Spike D614G variant, one RBD-up conformation 1

7EAZ の概要

• エントリーDOI: 10.2210/pdb7eaz/pdb
• EMDBエントリー: 31047
• 分子名称: Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, spike protein, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 443979.33

構造登録者

Yang, T.J.,Yu, P.Y.,Chang, Y.C.,Hsu, S.T.D. (登録日: 2021-03-08, 公開日: 2021-06-23, 最終更新日: 2022-01-05)

• 主引用文献: Yang, T.J.,Yu, P.Y.,Chang, Y.C.,Hsu, S.D.; D614G mutation in the SARS-CoV-2 spike protein enhances viral fitness by desensitizing it to temperature-dependent denaturation.; J.Biol.Chem., 297:101238-101238, 2021; PubMed: 34563540; DOI: 10.1016/j.jbc.2021.101238

実験手法

ELECTRON MICROSCOPY (3.5 Å)