7E4Y

Crystal structure of tubulin in complex with L-DM4-SMe

7E4Y の概要

• エントリーDOI: 10.2210/pdb7e4y/pdb
• 分子名称: Tubulin alpha-1B chain, (1S,2S,3S,5R,6S,16E,18E,20S,21R)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-methyl-3-(methyldisulfanyl)butanoyl]amino}propanoate (non-preferred name), PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: microtubule assembly inhibitors, structural protein-inhibitor complex, structural protein/inhibitor
• 由来する生物種: Bos taurus (Bovine); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 258551.21

構造登録者

Wang, Y.,Li, W. (登録日: 2021-02-16, 公開日: 2022-02-23, 最終更新日: 2023-11-29)

• 主引用文献: Wang, Y.,Li, W.; C3 Ester Side Chain Plays a Pivotal Role in the Antitumor Activity of Maytansinoids; To Be Published,

実験手法

X-RAY DIFFRACTION (2.708 Å)