7E3D

Crystal structure of human acetylcholinesterase

Summary for 7E3D

• Entry DOI: 10.2210/pdb7e3d/pdb
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, ... (4 entities in total)
• Functional Keywords: human acetylcholinesterase, hache, alzheimer's disease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 119977.25

Authors

Dileep, K.V.,Ihara, K.,Mishima-Tsumagari, C.,Kukimoto-Niino, M.,Yonemochi, M.,Hanada, K.,Shirouzu, M.,Zhang, K.Y.J. (deposition date: 2021-02-08, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Dileep, K.,Ihara, K.,Mishima-Tsumagari, C.,Kukimoto-Niino, M.,Yonemochi, M.,Hanada, K.,Shirouzu, M.,Zhang, K.Y.; Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery; Int.J.Biol.Macromol., 210:172-181, 2022; DOI: 10.1016/j.ijbiomac.2022.05.009

Experimental method

X-RAY DIFFRACTION (2.5 Å)