7E0P

Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 4-(((6-Bromo-1H-indazol-4-yl)amino)methyl)phenol (2)

7E0P の概要

• エントリーDOI: 10.2210/pdb7e0p/pdb
• 分子名称: Indoleamine 2,3-dioxygenase 1, 4-[[(6-bromanyl-1~{H}-indazol-4-yl)amino]methyl]phenol, PROTOPORPHYRIN IX CONTAINING FE, ... (5 entities in total)
• 機能のキーワード: indoleamine 2, 3-dioxygenase 1, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90150.87

構造登録者

Li, G.-B.,Ning, X.-L. (登録日: 2021-01-28, 公開日: 2021-07-21, 最終更新日: 2023-11-29)

• 主引用文献: Ning, X.L.,Li, Y.Z.,Huo, C.,Deng, J.,Gao, C.,Zhu, K.R.,Wang, M.,Wu, Y.X.,Yu, J.L.,Ren, Y.L.,Luo, Z.Y.,Li, G.,Chen, Y.,Wang, S.Y.,Peng, C.,Yang, L.L.,Wang, Z.Y.,Wu, Y.,Qian, S.,Li, G.B.; X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.; J.Med.Chem., 64:8303-8332, 2021; PubMed: 34110158; DOI: 10.1021/acs.jmedchem.1c00303

実験手法

X-RAY DIFFRACTION (2.635 Å)