7E0A

X-ray structure of human PPARgamma ligand binding domain-saroglitazar co-crystals obtained by co-crystallization

Summary for 7E0A

Entry DOI	10.2210/pdb7e0a/pdb
Descriptor	Isoform 2 of Peroxisome proliferator-activated receptor gamma, (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid (3 entities in total)
Functional Keywords	nuclear receptor, protein-ligand complex, ppar, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32417.65
Authors	Kamata, S.,Honda, A.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. (deposition date: 2021-01-27, release date: 2021-09-08, Last modification date: 2023-11-29)
Primary citation	Honda, A.,Kamata, S.,Satta, C.,Machida, Y.,Uchii, K.,Terasawa, K.,Nemoto, A.,Oyama, T.,Ishii, I. Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR alpha / gamma Dual Agonist. Biol.Pharm.Bull., 44:1210-1219, 2021 Cited by PubMed: 34471049 DOI: 10.1248/bpb.b21-00232 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.771 Å)

Structure validation