7E0A

X-ray structure of human PPARgamma ligand binding domain-saroglitazar co-crystals obtained by co-crystallization

7E0A の概要

• エントリーDOI: 10.2210/pdb7e0a/pdb
• 分子名称: Isoform 2 of Peroxisome proliferator-activated receptor gamma, (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid (3 entities in total)
• 機能のキーワード: nuclear receptor, protein-ligand complex, ppar, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32417.65

構造登録者

Kamata, S.,Honda, A.,Uchii, K.,Machida, Y.,Oyama, T.,Ishii, I. (登録日: 2021-01-27, 公開日: 2021-09-08, 最終更新日: 2023-11-29)

• 主引用文献: Honda, A.,Kamata, S.,Satta, C.,Machida, Y.,Uchii, K.,Terasawa, K.,Nemoto, A.,Oyama, T.,Ishii, I.; Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR alpha / gamma Dual Agonist.; Biol.Pharm.Bull., 44:1210-1219, 2021; PubMed: 34471049; DOI: 10.1248/bpb.b21-00232

実験手法

X-RAY DIFFRACTION (1.771 Å)