7DYW

Human JMJD5 in complex with MN and 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid.

Summary for 7DYW

Entry DOI	10.2210/pdb7dyw/pdb
Descriptor	Bifunctional peptidase and arginyl-hydroxylase JMJD5, 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	jmjc domain-containing protein 5, jmjd5, dioxygenase, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	27747.22
Authors	Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2021-01-23, release date: 2022-02-02, Last modification date: 2023-12-06)
Primary citation	Brewitz, L.,Nakashima, Y.,Piasecka, S.K.,Salah, E.,Fletcher, S.C.,Tumber, A.,Corner, T.P.,Kennedy, T.J.,Fiorini, G.,Thalhammer, A.,Christensen, K.E.,Coleman, M.L.,Schofield, C.J. 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66:10849-10865, 2023 Cited by PubMed: 37527664 DOI: 10.1021/acs.jmedchem.3c01114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation