7DYW

Human JMJD5 in complex with MN and 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid.

7DYW の概要

• エントリーDOI: 10.2210/pdb7dyw/pdb
• 分子名称: Bifunctional peptidase and arginyl-hydroxylase JMJD5, 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid, MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: jmjc domain-containing protein 5, jmjd5, dioxygenase, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27747.22

構造登録者

Nakashima, Y.,Brewitz, L.,Schofield, C.J. (登録日: 2021-01-23, 公開日: 2022-02-02, 最終更新日: 2023-12-06)

• 主引用文献: Brewitz, L.,Nakashima, Y.,Piasecka, S.K.,Salah, E.,Fletcher, S.C.,Tumber, A.,Corner, T.P.,Kennedy, T.J.,Fiorini, G.,Thalhammer, A.,Christensen, K.E.,Coleman, M.L.,Schofield, C.J.; 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.; J.Med.Chem., 66:10849-10865, 2023; PubMed: 37527664; DOI: 10.1021/acs.jmedchem.3c01114

実験手法

X-RAY DIFFRACTION (2.13 Å)