7DYU
Human JMJD5 in complex with MN and 5-((4-phenylbutyl)amino)pyridine-2,4-dicarboxylic acid.
Summary for 7DYU
Entry DOI | 10.2210/pdb7dyu/pdb |
Descriptor | Bifunctional peptidase and arginyl-hydroxylase JMJD5, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | jmjc domain-containing protein 5, jmjd5, dioxygenase, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27875.43 |
Authors | Nakashima, Y.,Brewitz, L.,Schofield, C.J. (deposition date: 2021-01-23, release date: 2022-02-02, Last modification date: 2023-12-06) |
Primary citation | Brewitz, L.,Nakashima, Y.,Piasecka, S.K.,Salah, E.,Fletcher, S.C.,Tumber, A.,Corner, T.P.,Kennedy, T.J.,Fiorini, G.,Thalhammer, A.,Christensen, K.E.,Coleman, M.L.,Schofield, C.J. 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66:10849-10865, 2023 Cited by PubMed: 37527664DOI: 10.1021/acs.jmedchem.3c01114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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