7DQ8
Crystal structure of actinomycin D-echinomycin-d(ACGCGCT/AGCTCGT) complex
Summary for 7DQ8
Entry DOI | 10.2210/pdb7dq8/pdb |
Related PRD ID | PRD_000001 PRD_000491 |
Descriptor | DNA (5'-D(P*AP*GP*CP*TP*CP*GP*T)-3'), DNA (5'-D(P*AP*CP*GP*CP*GP*CP*T)-3'), Echinomycin, ... (7 entities in total) |
Functional Keywords | drug-dna complex, dna mismatch, dna unwinding, dna deformation, dna, antibiotic-dna complex, antibiotic/dna |
Biological source | Streptomyces sp. More |
Total number of polymer chains | 4 |
Total formula weight | 6757.79 |
Authors | Satange, R.B.,Hou, M.H. (deposition date: 2020-12-22, release date: 2021-12-29, Last modification date: 2024-07-10) |
Primary citation | Satange, R.,Chang, C.C.,Li, L.Y.,Lin, S.H.,Neidle, S.,Hou, M.H. Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects. Nucleic Acids Res., 2023 Cited by PubMed: 36919604DOI: 10.1093/nar/gkad156 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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