7DPP

SARS-CoV-2 3CL protease (3CLpro) in complex with myricetin

7DPP の概要

• エントリーDOI: 10.2210/pdb7dpp/pdb
• 分子名称: 3C-like proteinase, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE (3 entities in total)
• 機能のキーワード: sars-cov-2, 3clpro, inhibitor, complex, myricetin, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33611.20

構造登録者

Su, H.X.,Zhao, W.F.,Xie, H.,Li, M.J.,Xu, Y.C. (登録日: 2020-12-21, 公開日: 2021-05-12, 最終更新日: 2023-11-29)

• 主引用文献: Su, H.,Yao, S.,Zhao, W.,Zhang, Y.,Liu, J.,Shao, Q.,Wang, Q.,Li, M.,Xie, H.,Shang, W.,Ke, C.,Feng, L.,Jiang, X.,Shen, J.,Xiao, G.,Jiang, H.,Zhang, L.,Ye, Y.,Xu, Y.; Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease.; Nat Commun, 12:3623-3623, 2021; PubMed: 34131140; DOI: 10.1038/s41467-021-23751-3

実験手法

X-RAY DIFFRACTION (2.1 Å)