7DP5

Crystal structure of mutant V45A Brugia malayi thymidylate synthase complexed with 2'-deoxyuridine monophosphate and methotrexate

7DP5 の概要

• エントリーDOI: 10.2210/pdb7dp5/pdb
• 分子名称: Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, METHOTREXATE, ... (6 entities in total)
• 機能のキーワード: thymidylate synthase, nucleotide synthase, transferase, methyltransferase
• 由来する生物種: Brugia malayi (Filarial nematode worm)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35597.46

構造登録者

Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B. (登録日: 2020-12-18, 公開日: 2021-12-22, 最終更新日: 2023-11-29)

• 主引用文献: Keyunratsami, K.,Nualnoi, T.,Wongkamchai, S.,Songsiriritthigul, C.,Chen, C.-J.,Canyuk, B.; Crystallographic investigation and inhibition of Brugia malayi thymidylate synthase by a folate analog; To Be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)