7DHK

The co-crystal structure of DYRK2 with a small molecule inhibitor 13

Summary for 7DHK

• Entry DOI: 10.2210/pdb7dhk/pdb
• Descriptor: Dual specificity tyrosine-phosphorylation-regulated kinase 2, 2-methoxy-7-phenylmethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine (3 entities in total)
• Functional Keywords: kinase, inhibitor, cell cycle
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38120.22

Authors

Wei, T.,Xiao, J. (deposition date: 2020-11-16, release date: 2021-11-17, Last modification date: 2023-11-29)

• Primary citation: Wei, T.,Wang, J.,Liang, R.,Chen, W.,Chen, Y.,Ma, M.,He, A.,Du, Y.,Zhou, W.,Zhang, Z.,Zeng, X.,Wang, C.,Lu, J.,Guo, X.,Chen, X.W.,Wang, Y.,Tian, R.,Xiao, J.,Lei, X.; Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry.; Elife, 11:-, 2022; PubMed: 35439114; DOI: 10.7554/eLife.77696

Experimental method