7DCX

S-3C1-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 3C1 fab.

7DCX の概要

• エントリーDOI: 10.2210/pdb7dcx/pdb
• EMDBエントリー: 30641
• 分子名称: The heavy chain of 3C1 fab that binds with the up RBD, Spike glycoprotein, The light chain of 3C1 fab (3 entities in total)
• 機能のキーワード: viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 564297.06

構造登録者

Cong, Y.,Liu, C.X. (登録日: 2020-10-27, 公開日: 2020-12-02, 最終更新日: 2021-03-10)

• 主引用文献: Zhang, C.,Wang, Y.,Zhu, Y.,Liu, C.,Gu, C.,Xu, S.,Wang, Y.,Zhou, Y.,Wang, Y.,Han, W.,Hong, X.,Yang, Y.,Zhang, X.,Wang, T.,Xu, C.,Hong, Q.,Wang, S.,Zhao, Q.,Qiao, W.,Zang, J.,Kong, L.,Wang, F.,Wang, H.,Qu, D.,Lavillette, D.,Tang, H.,Deng, Q.,Xie, Y.,Cong, Y.,Huang, Z.; Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections.; Nat Commun, 12:264-264, 2021; PubMed: 33431876; DOI: 10.1038/s41467-020-20465-w

実験手法

ELECTRON MICROSCOPY (5.9 Å)