7D8T

MITF bHLHLZ complex with M-box DNA

Summary for 7D8T

• Entry DOI: 10.2210/pdb7d8t/pdb
• Related: 7D8S
• Descriptor: DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit (3 entities in total)
• Functional Keywords: transcription factor, transcription, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 55339.34

Authors

Guo, M.,Fang, P.,Wang, J. (deposition date: 2020-10-09, release date: 2021-10-13, Last modification date: 2023-11-29)

• Primary citation: Liu, Z.,Chen, K.,Dai, J.,Xu, P.,Sun, W.,Liu, W.,Zhao, Z.,Bennett, S.P.,Li, P.,Ma, T.,Lin, Y.,Kawakami, A.,Yu, J.,Wang, F.,Wang, C.,Li, M.,Chase, P.,Hodder, P.,Spicer, T.P.,Scampavia, L.,Cao, C.,Pan, L.,Dong, J.,Chen, Y.,Yu, B.,Guo, M.,Fang, P.,Fisher, D.E.,Wang, J.; A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy.; Cell Res., 33:55-70, 2023; PubMed: 36588115; DOI: 10.1038/s41422-022-00744-5

Experimental method

X-RAY DIFFRACTION (3.201 Å)