7D8T
MITF bHLHLZ complex with M-box DNA
Summary for 7D8T
Entry DOI | 10.2210/pdb7d8t/pdb |
Related | 7D8S |
Descriptor | DNA (5'-D(P*GP*GP*GP*AP*CP*AP*CP*AP*TP*GP*TP*TP*AP*CP*AP*G)-3'), DNA (5'-D(*TP*GP*TP*AP*AP*CP*AP*TP*GP*TP*GP*TP*CP*CP*CP*C)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit (3 entities in total) |
Functional Keywords | transcription factor, transcription, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 55339.34 |
Authors | |
Primary citation | Liu, Z.,Chen, K.,Dai, J.,Xu, P.,Sun, W.,Liu, W.,Zhao, Z.,Bennett, S.P.,Li, P.,Ma, T.,Lin, Y.,Kawakami, A.,Yu, J.,Wang, F.,Wang, C.,Li, M.,Chase, P.,Hodder, P.,Spicer, T.P.,Scampavia, L.,Cao, C.,Pan, L.,Dong, J.,Chen, Y.,Yu, B.,Guo, M.,Fang, P.,Fisher, D.E.,Wang, J. A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33:55-70, 2023 Cited by PubMed: 36588115DOI: 10.1038/s41422-022-00744-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.201 Å) |
Structure validation
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