7D79
The structure of DcsB complex with its substrate analogue
Summary for 7D79
| Entry DOI | 10.2210/pdb7d79/pdb |
| Descriptor | DltD domain-containing protein, CHLORIDE ION, 1,2-ETHANEDIOL, ... (8 entities in total) |
| Functional Keywords | thioesterase, complex, hydrolase |
| Biological source | Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus) |
| Total number of polymer chains | 4 |
| Total formula weight | 141839.02 |
| Authors | Tang, Y.,Zhou, J.H.,Wang, G.Q. (deposition date: 2020-10-03, release date: 2021-01-27, Last modification date: 2024-03-27) |
| Primary citation | Gao, D.W.,Jamieson, C.S.,Wang, G.,Yan, Y.,Zhou, J.,Houk, K.N.,Tang, Y. A Polyketide Cyclase That Forms Medium-Ring Lactones. J.Am.Chem.Soc., 143:80-84, 2021 Cited by PubMed Abstract: Medium-ring lactones are synthetically challenging due to unfavorable energetics involved in cyclization. We have discovered a thioesterase enzyme DcsB, from the decarestrictine C1 () biosynthetic pathway, that efficiently performs medium-ring lactonizations. DcsB shows broad substrate promiscuity toward linear substrates that vary in lengths and substituents, and is a potential biocatalyst for lactonization. X-ray crystal structure and computational analyses provide insights into the molecular basis of catalysis. PubMed: 33351624DOI: 10.1021/jacs.0c11226 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.10411425302 Å) |
Structure validation
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