7D6H

Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant

Summary for 7D6H

• Entry DOI: 10.2210/pdb7d6h/pdb
• Descriptor: Papain-like protease, ZINC ION, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: protease, deubiquitinase, viral protein, hydrolase
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 1
• Total formula weight: 36271.31

Authors

Liu, J.,Wang, Y.,Pan, L. (deposition date: 2020-09-30, release date: 2020-11-04, Last modification date: 2023-11-29)

• Primary citation: Shan, H.,Liu, J.,Shen, J.,Dai, J.,Xu, G.,Lu, K.,Han, C.,Wang, Y.,Xu, X.,Tong, Y.,Xiang, H.,Ai, Z.,Zhuang, G.,Hu, J.,Zhang, Z.,Li, Y.,Pan, L.,Tan, L.; Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2.; Cell Chem Biol, 28:855-865.e9, 2021; PubMed: 33979649; DOI: 10.1016/j.chembiol.2021.04.020

Experimental method

X-RAY DIFFRACTION (1.6 Å)