7D1O
Crystal structure of SARS-Cov-2 main protease with narlaprevir
Summary for 7D1O
Entry DOI | 10.2210/pdb7d1o/pdb |
Descriptor | 3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total) |
Functional Keywords | sars-cov-2, main protease, narlaprevir, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 1 |
Total formula weight | 34535.53 |
Authors | |
Primary citation | Bai, Y.,Ye, F.,Feng, Y.,Liao, H.,Song, H.,Qi, J.,Gao, G.F.,Tan, W.,Fu, L.,Shi, Y. Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir. Signal Transduct Target Ther, 6:51-51, 2021 Cited by PubMed: 33542181DOI: 10.1038/s41392-021-00468-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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