7D1O

Crystal structure of SARS-Cov-2 main protease with narlaprevir

7D1O の概要

• エントリーDOI: 10.2210/pdb7d1o/pdb
• 分子名称: 3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropylamino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• 機能のキーワード: sars-cov-2, main protease, narlaprevir, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34535.53

構造登録者

Fu, L.F.,Feng, Y.,Qi, J.X. (登録日: 2020-09-15, 公開日: 2020-09-23, 最終更新日: 2023-11-29)

• 主引用文献: Bai, Y.,Ye, F.,Feng, Y.,Liao, H.,Song, H.,Qi, J.,Gao, G.F.,Tan, W.,Fu, L.,Shi, Y.; Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir.; Signal Transduct Target Ther, 6:51-51, 2021; PubMed: 33542181; DOI: 10.1038/s41392-021-00468-9

実験手法

X-RAY DIFFRACTION (1.78 Å)