7D0L

The major capsid of Omono River virus (strain:LZ), protrusion-free status.

7D0L の概要

• エントリーDOI: 10.2210/pdb7d0l/pdb
• EMDBエントリー: 30538
• 分子名称: Capsid protein (1 entity in total)
• 機能のキーワード: totiviridae, major capsid, viral protein, virus
• 由来する生物種: Omono River virus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 193721.98

構造登録者

Shao, Q.,Jia, X.,Gao, Y.,Liu, Z. (登録日: 2020-09-11, 公開日: 2021-03-03, 最終更新日: 2024-03-27)

主引用文献

Shao, Q.,Jia, X.,Gao, Y.,Liu, Z.,Zhang, H.,Tan, Q.,Zhang, X.,Zhou, H.,Li, Y.,Zhang, Q.
Cryo-EM reveals a previously unrecognized structural protein of a dsRNA virus implicated in its extracellular transmission.
Plos Pathog., 17:e1009396-e1009396, 2021

PubMed Abstract: Mosquito viruses cause unpredictable outbreaks of disease. Recently, several unassigned viruses isolated from mosquitoes, including the Omono River virus (OmRV), were identified as totivirus-like viruses, with features similar to those of the Totiviridae family. Most reported members of this family infect fungi or protozoans and lack an extracellular life cycle stage. Here, we identified a new strain of OmRV and determined high-resolution structures for this virus using single-particle cryo-electron microscopy. The structures feature an unexpected protrusion at the five-fold vertex of the capsid. Disassociation of the protrusion could result in several conformational changes in the major capsid. All these structures, together with some biological results, suggest the protrusions' associations with the extracellular transmission of OmRV.

PubMed: 33730056
DOI: 10.1371/journal.ppat.1009396

実験手法

ELECTRON MICROSCOPY (2.95 Å)