7CWG

Crystal structure of PDE8A catalytic domain in complex with 3a

7CWG の概要

• エントリーDOI: 10.2210/pdb7cwg/pdb
• 分子名称: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: camp-specific, hydrolase, selective pde8a inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39534.48

構造登録者

Huang, Y.,Wu, X.-N.,Zhou, Q.,Wu, Y.,Luo, H.-B. (登録日: 2020-08-28, 公開日: 2021-09-01, 最終更新日: 2023-11-29)

• 主引用文献: Huang, Y.,Wu, X.N.,Zhou, Q.,Wu, Y.,Zheng, D.,Li, Z.,Guo, L.,Luo, H.B.; Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.; J.Med.Chem., 63:15852-15863, 2020; PubMed: 33291877; DOI: 10.1021/acs.jmedchem.0c01573

実験手法

X-RAY DIFFRACTION (2.8 Å)