7CUU

Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with MG132

Summary for 7CUU

Entry DOI	10.2210/pdb7cuu/pdb
Related PRD ID	PRD_001210
Descriptor	3C protein, DIMETHYL SULFOXIDE, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide, ... (5 entities in total)
Functional Keywords	sars-cov-2, 3cl, inhibitor, complex, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains	2
Total formula weight	69038.92
Authors	Lu, M.,Yang, H.T.,Wang, Z.Y.,Zhao, Y.,Xing, Y.F. (deposition date: 2020-08-24, release date: 2021-06-23, Last modification date: 2023-11-29)
Primary citation	Wang, Z.,Zhao, Y.,Wang, Q.,Xing, Y.,Feng, L.,Kong, J.,Peng, C.,Zhang, L.,Yang, H.,Lu, M. Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M pro . Signal Transduct Target Ther, 6:214-214, 2021 Cited by PubMed: 34075025 DOI: 10.1038/s41392-021-00639-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation