7CRF

Crystal structure of human TLR8 in complex with CU-CPD107

7CRF の概要

• エントリーDOI: 10.2210/pdb7crf/pdb
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 196905.83

構造登録者

Sakaniwa, K.,Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2020-08-13, 公開日: 2021-06-23, 最終更新日: 2023-11-29)

• 主引用文献: Yang, Y.,Csakai, A.,Jiang, S.,Smith, C.,Tanji, H.,Huang, J.,Jones, T.,Sakaniwa, K.,Broadwell, L.,Shi, C.,Soti, S.,Ohto, U.,Fang, Y.,Shen, S.,Deng, F.,Shimizu, T.,Yin, H.; Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.; Nat Commun, 12:4351-4351, 2021; PubMed: 34272380; DOI: 10.1038/s41467-021-24536-4

実験手法

X-RAY DIFFRACTION (2.89 Å)