7CP4

Crystal Structure of PAK4 in complex with inhibitor 55

Summary for 7CP4

• Entry DOI: 10.2210/pdb7cp4/pdb
• Descriptor: Serine/threonine-protein kinase PAK 4, [1-(2-azanylpyrimidin-4-yl)-6-[2-(1-oxidanylcyclohexyl)ethynyl]indol-3-yl]-[(3S)-3-methylpiperazin-1-yl]methanone (3 entities in total)
• Functional Keywords: atp binding pocket, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33469.93

Authors

Zhao, F.,Li, H. (deposition date: 2020-08-06, release date: 2021-08-11, Last modification date: 2023-11-29)

• Primary citation: Song, P.,Zhao, F.,Cheng, M.; Discovery of 6-ethynyl-1H-indole-3-carboxamide Derivatives as Highly Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors; to be published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)