7CP3

Crystal Structure of PAK4 in complex with inhibitor 47

7CP3 の概要

• エントリーDOI: 10.2210/pdb7cp3/pdb
• 分子名称: Serine/threonine-protein kinase PAK 4, [(3R)-3-azanylpiperidin-1-yl]-[1-(2-azanylpyrimidin-4-yl)-6-[2-(1-oxidanylcyclohexyl)ethynyl]indol-3-yl]methanone (2 entities in total)
• 機能のキーワード: atp binding pocket, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33469.93

構造登録者

Zhao, F.,Li, H. (登録日: 2020-08-05, 公開日: 2021-08-11, 最終更新日: 2023-11-29)

• 主引用文献: Song, P.,Zhao, F.,Cheng, M.; Discovery of 6-ethynyl-1H-indole-3-carboxamide Derivatives as Highly Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors; to be published,

実験手法

X-RAY DIFFRACTION (2.9 Å)