7CMW
Complex structure of PARP1 catalytic domain with pamiparib
Summary for 7CMW
Entry DOI | 10.2210/pdb7cmw/pdb |
Descriptor | Poly [ADP-ribose] polymerase 1, (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | parp1, pamiparib, bgb-290, transferase, antitumor protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 80037.47 |
Authors | Feng, Y.C.,Peng, H.,Hong, Y.,Liu, Y. (deposition date: 2020-07-29, release date: 2020-12-16, Last modification date: 2023-11-29) |
Primary citation | Wang, H.,Ren, B.,Liu, Y.,Jiang, B.,Guo, Y.,Wei, M.,Luo, L.,Kuang, X.,Qiu, M.,Lv, L.,Xu, H.,Qi, R.,Yan, H.,Xu, D.,Wang, Z.,Huo, C.X.,Zhu, Y.,Zhao, Y.,Wu, Y.,Qin, Z.,Su, D.,Tang, T.,Wang, F.,Sun, X.,Feng, Y.,Peng, H.,Wang, X.,Gao, Y.,Liu, Y.,Gong, W.,Yu, F.,Liu, X.,Wang, L.,Zhou, C. Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. J.Med.Chem., 63:15541-15563, 2020 Cited by PubMed: 33264017DOI: 10.1021/acs.jmedchem.0c01346 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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