7C8T

Complex Structure of SARS-CoV-2 3CL Protease with TG-0205221

7C8T の概要

• エントリーDOI: 10.2210/pdb7c8t/pdb
• 分子名称: 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE (3 entities in total)
• 機能のキーワード: inhibitor, complex, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34428.31

構造登録者

Lee, C.C.,Wang, A.H.J.,Kuo, C.J.,Liang, P.H. (登録日: 2020-06-03, 公開日: 2020-06-17, 最終更新日: 2024-10-30)

• 主引用文献: Kuo, C.J.,Shie, J.J.,Lin, C.H.,Lin, Y.L.,Hsieh, M.C.,Lee, C.C.,Chang, S.Y.,Wang, A.H.J.,Liang, P.H.; Complex Structures and Cellular Activities of the Potent SARS-CoV-2 3CLpro Inhibitors Guiding Drug Discovery Against COVID-19; To Be Published,

実験手法

X-RAY DIFFRACTION (2.05 Å)